Manus Bio publishes on the potential of microbial fermentation for delivering low-calorie or zero-calorie sweeteners

CAMBRIDGE, Mass., February 3, 2014 - Manus Bio scientists have published a review article entitled “Biotechnological production of natural zero-calorie sweeteners.” The paper was published in Current Opinion in Biotechnology (

Increased public awareness on the adverse health effects of excessive sugar consumption has led to a resurgence in interest in plant-derived, natural low-calorie or zero-calorie sweeteners. The published article delves into the properties of high-potency natural sweeteners from two plant species, Stevia rebaudiana and Siraitia grosvenorii, and describes the key biotechnological innovations necessary to realize commercial-scale production of these important ingredients. “There remains a strong need for high performing natural sweeteners to replace sugar in a variety of food and beverage products” said Dr. Ajikumar Parayil, Ph.D., Co-Founder and Chief Technology Officer of Manus Bio. “At Manus Bio, we are committed to applying our advanced microbial platform to deliver non-caloric sweeteners which can have a positive impact on human nutrition and health.”

About Manus Bio

Manus Bio is a global leader in the use of advanced fermentation technology for manufacturing complex, bioactive natural products as flavors, fragrances, food ingredients, biopesticides, and pharmaceuticals. The core team and technology are from MIT, and the company is headquartered in Cambridge, MA, USA. For more information, visit