GLOBE NEWSWIRE |  Cambridge, Mass.07 Mar 2016

Manus Bio describes advanced techniques for engineering oxygenation chemistry

Manus Bio scientists have published an article entitled “Overcoming heterologous protein interdependency to optimize P450-mediated Taxol precursor synthesis in Escherichia coli.” The paper was published in the Proceedings of the National Academy of Sciences (

Through this work, Manus Bio scientists demonstrate key insights for optimizing oxygenation chemistry for the synthesis of complex plant-based ingredients and achieve the highest reported titer of oxygenated precursors for Taxol production. “These results underscore the importance of an integrated approach combining metabolic engineering, synthetic biology, and deep strain characterization for commercial strain development,” says Dr. Ajikumar Parayil, Ph.D., Co-Founder and Chief Technology Officer of Manus Bio.

Manus Bio leverages rapid advances in Biology to produce complex natural ingredients used in our daily lives as flavors, fragrances, food ingredients, cosmetics, vitamins, pharmaceuticals and agricultural chemicals. Using its advanced fermentation technology, Manus Bio recreates natural processes for next-generation industrial biomanufacturing and provides sustainable and cost-effective sources of ingredients for health, wellness, and nutrition. To learn more, visit