GLOBE NEWSWIRE |  Cambridge, Mass.11 Jun 2014

Manus Bio publishes on a metabolic engineering framework for efficient and low-cost commercial strain development

Manus Bio scientists have published a review article entitled “Multivariate modular metabolic engineering for pathway and strain optimization” in collaboration with Prof. Marjan De Mey from Ghent University. The paper was published in Current Opinion in Biotechnology (

The paper describes the tenets of a novel metabolic engineering framework which enables a low-cost and efficient semi-combinatorial route for developing commercial strains. The core technology was founded by Professor Greg Stephanopoulos (Massachusetts Institute of Technology, MIT) and Dr. Ajikumar Parayil, Ph.D., Co-Founder and Chief Technology Officer of Manus Bio during his time as a research fellow at MIT. “Unlike purely combinatorial approaches which require heavy investments in both library construction and screening, the multivariate modular metabolic engineering approach enables rapid strain optimization through guided semi-combinatorial library design,” says Dr. Ajikumar Parayil. “This means that it has the versatility to be rapidly deployed in a variety of hosts for a number of important pathways and systems.”

Manus Bio leverages rapid advances in Biology to produce complex natural ingredients used in our daily lives as flavors, fragrances, food ingredients, cosmetics, vitamins, pharmaceuticals and agricultural chemicals. Using its advanced fermentation technology, Manus Bio recreates natural processes for next-generation industrial biomanufacturing and provides sustainable and cost-effective sources of ingredients for health, wellness, and nutrition. To learn more, visit