GLOBE NEWSWIRE |  Cambridge, Mass.03 Feb 2014

Manus Bio publishes on the potential of microbial fermentation for delivering low-calorie or zero-calorie sweeteners

Manus Bio scientists have published a review article entitled “Biotechnological production of natural zero-calorie sweeteners.” The paper was published in Current Opinion in Biotechnology (

Increased public awareness on the adverse health effects of excessive sugar consumption has led to a resurgence in interest in plant-derived, natural low-calorie or zero-calorie sweeteners. The published article delves into the properties of high-potency natural sweeteners from two plant species, Stevia rebaudiana and Siraitia grosvenorii, and describes the key biotechnological innovations necessary to realize commercial-scale production of these important ingredients. “There remains a strong need for high performing natural sweeteners to replace sugar in a variety of food and beverage products” said Dr. Ajikumar Parayil, Ph.D., Co-Founder and Chief Technology Officer of Manus Bio. “At Manus Bio, we are committed to applying our advanced microbial platform to deliver non-caloric sweeteners which can have a positive impact on human nutrition and health.”

Manus Bio leverages rapid advances in Biology to produce complex natural ingredients used in our daily lives as flavors, fragrances, food ingredients, cosmetics, vitamins, pharmaceuticals and agricultural chemicals. Using its advanced fermentation technology, Manus Bio recreates natural processes for next-generation industrial biomanufacturing and provides sustainable and cost-effective sources of ingredients for health, wellness, and nutrition. To learn more, visit