Publications

Technology
  • pnas

    Overcoming heterologous protein interdependency to optimize P450-mediated Taxol precursor synthesis in Escherichia coli.

    Biggs BW, Lim CG, Sagliani K, Shankar S, Stephanopoulos G, De Mey M, Ajikumar PK Proc. Natl. Acad. Sci. U. S. A. 2016, 113:3209-3214.
  • ACS Bio

    Orthogonal Assays Clarify the Oxidative Biochemistry of Taxol.

    Biggs BW, Rouck JE, Kambalyal A, Arnold W, Lim CG, De Mey M, Neil-johnson MO, Starks CM, Das A, Ajikumar PK P450 CYP725A4. 2016, ACS Chem. Biol., doi:10.1021/acschembio.5b00968.
  • Curr Op Bio

    Multivariate modular metabolic engineering for pathway and strain optimization.

    Biggs BW, De Paepe B, Santos CNS, De Mey M, Ajikumar PK Curr. Opin. Biotechnol. 2014, 29:156–162.
  • Curr Op Bio

    Biotechnological production of natural zero-calorie sweeteners.

    Philippe RN, De Mey M, Anderson J, Ajikumar PK Curr. Opin. Biotechnol. 2014, 26C:155–161.
  • pnas

    Integrating the protein and metabolic engineering toolkits for next-generation chemical biosynthesis.

    Pirie CM, De Mey M, Prather KLJ, Ajikumar PK ACS Chem. Biol. 2013, 8:662–72.
  • ACS Bio

    Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control.

    Leonard E, Ajikumar PK, Thayer K, Xiao W, Mo JD, Tidor B, Stephanopoulos G, Prather KLJ Proc. Natl. Acad. Sci. U. S. A. 2010, 107:13654–9.
  • Science

    Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli.

    Ajikumar PK, Xiao W, Tyo KEJ, Wang Y, Simeon F, Leonard E, Mucha O, Phon TH, Pfeifer B, Stephanopoulos G Science. 2010, 330:70–74.