Ensuring Successful Commercialization,
One Step at a Time

Scientist in our Boston BioFacility working with an automated colony picker
Our scale-up platform covers the entire process, from cell factory design and engineering, to biomanufacturing at scale.

Unique expertise goes into each step of the development and scale-up process. This enables us to accelerate the creation and optimization of cell factories to perform complex chemistries at scale.
Scientist in our Boston BioFacility
working with an automated colony picker
SCIENCE AND TECHNOLOGY

The Manus Mantra dictates that we can continuously accelerate the optimization of biocatalysts to perform complex chemistries at scale.

Cell Factory Design

01

Our proprietary collection of optimized chassis hosts ensures easier scalability and significantly lower costs of development for new bioalternatives.

Cell Factory Engineering

02

Our unique cell factory engineering approach enables us to engineer metabolic pathways and enzymatic activity within a chassis host so efficiently that yields quickly reach required levels at scale.

Biomanufacturing

03

Our state-of-the art BioFacilities have the proven precision fermentation capacity for scale-up and large-volume production.

We help our customers overcome the technology, time, and capital constraints that often create a Valley of Death – ensuring promising strains reach manufacturing scale.

Bridging the Valley of Death

Technology, time, and capital constraints create a Valley of Death, preventing promising strains from reaching manufacturing scale.

Our end-to-end platform is the only one that integrates discovery, cell factory design and engineering, enzyme optimization, and precision fermentation. It bridges the Valley of Death faster and more reliably than anyone else.

Manus Valley of Death GraphicManus Valley of Death Graphic

A 48-culture array for cell factory
engineering in our Boston BioFacility

We help our customers overcome the technology, time, and capital constraints that often create a Valley of Death – ensuring promising strains reach manufacturing scale.

A Revolutionary Cell Factory
Engineering Approach

The platform is built on our patented BioOptimization CycleTM. It is a revolutionary data- and insight-driven cell factory engineering platform that ensures quick and effective scale-up from lab to manufacturing.

Manus Valley of Death GraphicManus Valley of Death Graphic

At Manus, we have a collection of “universal chassis” which have been engineered for high-yield and scalable production of the common building blocks to more than 150,000 complex molecules. Leveraging a wealth of digital biological data built over the last two decades, we discover and introduce novel enzymes and pathways to transform these chassis into cell factories for diverse products.

These cell factories are engineered for commercial-ready and scaled performance using our iterative BioOptimization Cycle combining metabolic engineering (product flux enhancement), enzyme engineering (biocatalyst development), and systems biology (quantitative cellular characterization) to quickly develop novel bioalternatives cell factories.

Our fully vertical capabilities allow us to characterize process performance all the way to finished product across all scales from bench to pilot to large-scale manufacturing throughout the development process to ensure high efficiencies and translatability. Our end-to-end scale-up platform enables the delivery of products – bioalternatives – just like nature, but Made by ManusTM.

Each part of the BioOptimization CycleTM contributes to the successful scale-up of any process

Metabolic Engineering

01

Our metabolic engineering framework allows us to efficiently optimize complex biological pathways for high yield and performance.

Enzyme Engineering

02

Our computational protein design platform augmented with AI has successfully optimized more than 40 distinct enzymes spanning 11 protein families.

System Bio Characterization

03

Our integrated multivariate omics analysis platform allows us to gather quantitative cellular information to efficiently guide our engineering process.

Cell factory engineering at our Boston BioFacility

Manus scientist using a programmable 96-channel pipette for cell factory engineering workflows, such as DNA purification and small-scale fermentations. The equipment enables higher, more efficient throughput manipulation in a 96-well format.

Answers to your
most common questions

001

What are the key advantages of working with Manus on both sides of the Valley of Death?

002

Can Manus’ technology be imitated by others?

003

Are there specific organisms that Manus works with?

Looking to cross the Valley of Death and put our scale-up process into action?