Ensuring Successful Commercialization,
One Step at a Time
Unique expertise goes into each step of the development and scale-up process. This enables us to accelerate the creation and optimization of cell factories to perform complex chemistries at scale.
working with an automated colony picker
The Manus Mantra dictates that we can continuously accelerate the optimization of biocatalysts to perform complex chemistries at scale.
Cell Factory Design
01
Our proprietary collection of optimized chassis hosts ensures easier scalability and significantly lower costs of development for new bioalternatives.
Cell Factory Engineering
02
Our unique cell factory engineering approach enables us to engineer metabolic pathways and enzymatic activity within a chassis host so efficiently that yields quickly reach required levels at scale.
Biomanufacturing
03
Our state-of-the art BioFacilities have the proven precision fermentation capacity for scale-up and large-volume production.
We help our customers overcome the technology, time, and capital constraints that often create a Valley of Death – ensuring promising strains reach manufacturing scale.
Bridging the Valley of Death
Technology, time, and capital constraints create a Valley of Death, preventing promising strains from reaching manufacturing scale.
Our end-to-end platform is the only one that integrates discovery, cell factory design and engineering, enzyme optimization, and precision fermentation. It bridges the Valley of Death faster and more reliably than anyone else.
A 48-culture array for cell factory
engineering in our Boston BioFacility
We help our customers overcome the technology, time, and capital constraints that often create a Valley of Death – ensuring promising strains reach manufacturing scale.
A Revolutionary Cell Factory
Engineering Approach
The platform is built on our patented BioOptimization CycleTM. It is a revolutionary data- and insight-driven cell factory engineering platform that ensures quick and effective scale-up from lab to manufacturing.
At Manus, we have a collection of “universal chassis” which have been engineered for high-yield and scalable production of the common building blocks to more than 150,000 complex molecules. Leveraging a wealth of digital biological data built over the last two decades, we discover and introduce novel enzymes and pathways to transform these chassis into cell factories for diverse products.
These cell factories are engineered for commercial-ready and scaled performance using our iterative BioOptimization Cycle combining metabolic engineering (product flux enhancement), enzyme engineering (biocatalyst development), and systems biology (quantitative cellular characterization) to quickly develop novel bioalternatives cell factories.
Our fully vertical capabilities allow us to characterize process performance all the way to finished product across all scales from bench to pilot to large-scale manufacturing throughout the development process to ensure high efficiencies and translatability. Our end-to-end scale-up platform enables the delivery of products – bioalternatives – just like nature, but Made by ManusTM.
Each part of the BioOptimization CycleTM contributes to the successful scale-up of any process
Metabolic Engineering
01
Our metabolic engineering framework allows us to efficiently optimize complex biological pathways for high yield and performance.
Enzyme Engineering
02
Our computational protein design platform augmented with AI has successfully optimized more than 40 distinct enzymes spanning 11 protein families.
System Bio Characterization
03
Our integrated multivariate omics analysis platform allows us to gather quantitative cellular information to efficiently guide our engineering process.
Cell factory engineering at our Boston BioFacility
Answers to your
most common questions
001
What are the key advantages of working with Manus on both sides of the Valley of Death?
002
Can Manus’ technology be imitated by others?
003
Are there specific organisms that Manus works with?
